Determinants of Changes in Arterial Load Following Exercise

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this study is to learn about how blood vessel dilation after exercise effects pulse wave reflection and influences the function of the heart in healthy young adults. The main question it aims to answer is: Are post-exercise decreases in reflected pulse waves due to a decrease in the stiffness of large arteries in the leg or an increase in leg blood flow? Participants will exercise on a stationary bicycle at a moderate intensity for 1 hour during two laboratory visits. Participants will take oral antihistamines to block post-exercise dilation at one visit, and they will take placebo pills at the other visit. At both visits, leg blood flow, pulse wave velocity, and heart function will be measured before exercise and for 120-minutes after exercise.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 45
Healthy Volunteers: t
View:

• healthy men and women

• sedentary or recreationally active

Locations
United States
Delaware
Department of Kinesiology and Applied Physiology, University of Delaware
RECRUITING
Newark
Contact Information
Primary
David Edwards, PhD
dge@udel.edu
302-831-3363
Backup
Jordan Patik, PhD
jpatik@udel.edu
5128206387
Time Frame
Start Date: 2023-05-12
Estimated Completion Date: 2024-09
Participants
Target number of participants: 25
Treatments
Experimental: Antihistamine
The oral antihistamine condition will consist of fexofenadine (540mg) and famotidine (40mg). Commercially available pills (3 x 180mg fexofenadine and 2 x 20mg famotidine) will be placed within opaque capsules and administered to the participants upon arrival to the laboratory.
Placebo_comparator: Placebo
The placebo condition will consist of dextrose in an identical number of opaque capsules as the antihistamine treatment. Total dextrose will be \<5g. The capsules will be administered to the participants upon arrival to the laboratory.
Sponsors
Leads: University of Delaware

This content was sourced from clinicaltrials.gov